The beloved BBC medical drama Casualty is returning from its scheduled break with more ambition and change than ever before. After a strong run in 2025, the show is launching into its next chapter with bold shifts in setting, cast dynamics and story elevation.

The next season is set to air late 2025, as confirmed by the broadcaster. One of the most exciting announcements is the move for Casualty from its long-standing fictional setting at Holby City Hospital to a new hospital location in Wales. According to the Wikipedia page, series 40 is the final one set in Holby, with the reset to a Welsh setting expected to begin thereafter.

Cast members are upbeat about the shift. In an exclusive interview, actors Milo Clarke and Olly Rix promised “a stronger” comeback for the show, pointing to the relocation as a creative turning point.The production appears to leverage the change in setting to refresh story possibilities, inject new characters and amplify tension.

Some key things to expect:

• A change of scene: The move to Wales signals significant upheaval for staff and patients alike. A new hospital setting can mean new rules, new tensions, and fresh storytelling scope.

• New faces + familiar ones: While many beloved characters will remain, the relocation promises new additions and role changes. The cast themselves have teased that despite the shift, viewer-favourites are expected to stay and anchor the show.

• Fresh narrative energy: With series 39 recently concluded and series 40 acting as a hinge, the show seems primed for a reinvention. According to information on Wikipedia, series 40 commenced 2 August 2025 and serves as a transitional phase.

• Scheduling & production updates: The show has taken breaks in its traditional time-slot due to production and scheduling needs. These pauses seem aligned with the forthcoming transformation.

For existing fans, this signals both comfort and change: the core of Casualty’s medical-drama heart remains, but the landscape is about to evolve dramatically. For new viewers, this is an opportune moment to jump in: the show is resetting its canvas, making it potentially more accessible without pre-existing baggage.

Why does this matter?

• The relocation to Wales isn’t just cosmetic: filming in Wales, working through Welsh NHS contexts, and featuring new regional storylines may open the show to fresh authenticity and audience appeal.

• Format-wise the show has been reorganising its mini-series arc structure in recent seasons, which may mean sharper, more serialized storytelling going forward. For example, series 39 was split into mini-series like Supply and Demand.

• From a brand perspective, after nearly four decades, this bold step helps revitalise the show and emphasise that “Casualty isn’t what it used to be” in the best way.

What to keep an eye on as the new season approaches:

• Which familiar characters are relocating and how they fit into the new hospital.

• How the Welsh setting is integrated—will we see regional NHS issues, new hospital culture, and different community-patient dynamics?

• Whether the format or episode cadence changes further (e.g., shorter seasons, different transmission schedule).

• How story arcs will launch: will the new location act as a catalyst for crises, or will there be more gradual character-driven rebuilding?

In short: the next season of Casualty promises to be a landmark moment for the show — a bridge between its legacy and a reinvigorated future.

Are you excited about the move to Wales and what that might mean for your favourite characters?